I think the answer is yes. They are different. Next question, please.

I wholeheartedly and fundamentally disagree with you. There is zero reason to do so. ZERO. It's understood.

Make it it's own line with no subsequent text adjacent to it.

"There will be now words said after the response. No confusion will be had. It’s understood as what it is."

Oops ... sorry "no words".

I had the same argument as Frank. Frank beat me to it. I would like to add that you can't put a period at the end of "Who knows" either. Not really, anyway. I think it needs zero punctuation. It is very plain to see that it is really a response to the question asked before. A simple response. Not a question. Not a rhetorical question. Not a statement. Not a sentence in full at all. just two words as a response and thus zero punctuation is needed. There will be now words said after the response. No confusion will be had. It's understood as what it is.